Meanwhile, for Munster's first game in the space of six months, there are debuts from the start for new signings Damian de Allende and RG Snyman - both World Cup winners with South Africa last year.
Cork native Shane Daly makes his fifth start at full-back, in his 18th appearance for the province, with Ireland internationals Andrew Conway and Keith Earls completing an exciting back-three.
De Allende, the former Western Province and Stormers back, links up with Chris Farrell in the centre, with the Reds' back-line marshalled by JJ Hanrahan, the scorer of 101 PRO14 points this term, and Conor Murray.
Snyman, who signed from Japanese club Honda Heat, packs down with Billy Holland in the engine room, supporting another all-international front row made up of James Cronin, Niall Scannell and Stephen Archer.
Captain Peter O'Mahony, Tommy O'Donnell and CJ Stander join forces in the loose forwards. Munster's back row ranks are missing Jack O'Donoghue who is unavailable after sustaining a concussion during training this week.
Johann van Graan's men are set to have a third debutant on the day, as ex-Saracen Matt Gallagher, the 23-year-old son of former All Black John Gallagher, is among their back-line replacement.