Carlow man Ed Byrne will lead out Leinster for the first time in a competitive fixture, captaining the Conference A table-toppers from the front row.
Head coach Leo Cullen has made the full 23 changes to his squad from the 27-25 derby win over Munster.
Loosehead Byrne, Sean Cronin, Michael Bent and Devin Toner are all promoted from the bench, with Ross Molony completing the tight five. Max Deegan anchors a back row that contains fellow Academy graduates Josh Murphy and Will Connors.
Rob Kearney wins his 219th provincial cap, slotting in at full-back for his first appearance since mid-February. The back-line is marshalled by Ross Byrne and half-back partner Jamison Gibson-Park, who is representing Leinster for the 90th time.
The wing spots are filled by Hugo Keenan and Cian Kelleher, who scored four tries in his last five games before the Coronavirus outbreak, while noted out-half Ciaran Frawley gets a first chance to impress in the inside centre position, alongside Rory O'Loughlin.
Tom Clarkson, the promising 20-year-old Academy prop, is poised to make his senior debut from the Leinster bench. The Dublin University clubman has impressed at tighthead for the Ireland Under-20s over the past 18 months.