Ireland forward Tadhg Beirne makes a welcome return to the Munster team. He is set to play for the first time since fracturing his ankle away to Saracens in the Heineken Champions Cup last December.
All five personnel changes are up front as Beirne, Jeremy Loughman, John Ryan, Fineen Wycherley and Chris Cloete are drafted in by head coach Johann van Graan. Beirne and Wycherley start together in the second row for the first time.
Loughman and Ryan, who turned 32 earlier this month, pack down with Niall Scannell in the front row, with captain Peter O'Mahony, Cloete and CJ Stander completing the Reds' starting pack.
The Munstermen field an unchanged back-line which includes JJ Hanrahan, the leading scorer in this season's Pro14 (111 points), and wingers Andrew Conway and Keith Earls who both touched down against Leinster. Corkman Shane Daly completes the back-three.
Conor Murray is retained at scrum half and there is a second successive start for the newly-formed centre pairing of Chris Farrell, last Saturday's man-of-the-match, and South African recruit Damian de Allende.
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Jack O'Donoghue, who returns from a concussion sustained in training last week, Kevin O'Byrne, Liam O'Connor and Jack O'Sullivan are all included among the replacements and are set for their first appearances since the return to rugby.